Clinical Notes : Urology

153. UTI in Adults under 65 years

UTI in Adults under 65

 

Women (under 65 years) with suspected UTI

This guide excludes patients with recurrent UTI (2 episodes in last 6 months, or 3 episodes in last 12 months)

 

Flowchart for women (under 65 years) with suspected UTI

UTI = Urinary Tract Infection

NICE = National Institute for Health and Care Excellence

RCGP = Royal College of General Practitioners

NEWS2 = National Early Warning Score 2

PHE = Public Health England

RBC = Red Blood Cells

TARGET = Treat AntibioticsResponsibly, Guidance, Education, Tools

Diagnostic points for men under 65 years

  • Asymptomatic bacteriuria is rare in men <65 years

 

  • Consider other genitourinary causes of urinary symptoms

  • In sexually active, check sexual history for STIs for example chlamydia and gonorrhoea

  • Urethritis due to urethral inflammation post sexual intercourse, irritants, or STIs

 

  • Check for pyelonephritis, prostatitis, systemic infection, or suspected sepsis using local policy

  • Urinary symptoms with fever or systemic symptoms in men are strongly suggestive of prostatic involvement or pyelonephritis

  • Acute prostatitis may present with feverish illness of sudden onset, symptoms of prostatitis (low back, suprapubic, perineal, or sometimes rectal pain), symptoms of UTI (dysuria, frequency, urgency or retention), or exquisitely tender prostate on rectal examination

  • Recurrent or relapsing UTI in men should prompt referral to urology for investigation

 

  • Diagnostic points in men

  • Always send a mid-stream urine sample for culture, collected before antibiotics are given

  • Dipsticks are poor at ruling out infection. Positive nitrite makes UTI more likely (positive predictive value 96%). Negative for both nitrite and leucocyte makes UTI less likely, especially if symptoms are mild

  • If suspected UTI, offer immediate treatment according to NICE/PHE guideline on lower UTI: antimicrobial prescribing and review choice of antibiotic with pre-treatment culture results

 
 

Sending urine for culture and interpreting results in all adults

  • Review need for culture when considering treatment

  • Send a urine for culture in:

    • over 65 year olds if symptomatic and antibiotic given

    • pregnancy: for routine antenatal tests, or if symptomatic

    • suspected pyelonephritis or sepsis

    • suspected UTI in men

    • failed antibiotic treatment or persistent symptoms

    • recurrent UTI (2 episodes in 6 months or 3 in 12 months)

    • if prescribing antibiotic in someone with a urinary catheter

    • as advised by local microbiologist

  • Consider risk factors for resistance and send urine for culture if:

    • abnormalities of genitourinary tract

    • renal impairment

    • care home resident

    • hospitalisation for >7 days in last 6 months

    • recent travel to a country with increased resistance

    • previous UTI resistant

  • If prescribing an antibiotic, review choice when culture and antibiotic susceptibility results are available

 

Sampling in all men and women

  • Women: mid-stream urine (NHS choices) and holding the labia apart may help reduce contamination but if not possible, sample can still be sent for culture

  • Do not cleanse with antiseptic, as bacteria may be inhibited

  • Elderly/frail: only take urine sample if symptomatic and able to collect good sample. If incontinent, clean catch in disinfected container and condom catheters for men may be viable options but little evidence to support

  • Men: advise on how to take a mid-stream specimen (NHS choices)

  • People with urinary catheters: if changed, collect from newly placed catheter using aseptic technique, drain a few mL of residual urine from the tubing, then collect a fresh sample from catheter sampling port

  • Culture urine within 4 hours of collection, refrigerate, or use boric acid preservative. Boric acid can cause false negative culture if urine not filled to correct mark on specimen bottle and can affect urine dipstick tests)

 

How do I interpret a urine culture result if I suspect a UTI?

  • Culture should be interpreted in parallel to severity of signs/symptoms. False negatives/positives can occur

  • Do not treat asymptomatic bacteriuria unless pregnant as it does not reduce mortality or morbidity

  • Urine culture results in patients with urinary symptoms that usually indicate UTI:

    • many labs use growth of 107–108 cfu/L (104–105  cfu/mL) to indicate UTI

    • lower counts can also indicate UTI if patient symptomatic:

      • strongly symptomatic women—single isolate ≥105 cfu/L (≥102 cfu/mL) in voided urine

      • in men counts as low as 106 cfu/L (103 cfu/mL) of a pure or predominant organism

      • any single organism ≥107 cfu/L (≥104 cfu/mL)

      • Escherichia coli or Staphylococcus saprophyticus ≥106 cfu/L (≥103 cfu/mL)

      • ≥108 cfu/L (≥105 cfu/mL) mixed growth with 1 predominant organism

  • Epithelial cells/mixed growth:

    • the presence of epithelial cells is not necessarily an indicator of perineal contamination, culture result should be interpreted with symptoms and repeated if significance is uncertain

    • mixed growth may indicate perineal contamination; however a small proportion of UTIs may be due to genuine mixed infection. Consider a re-test if symptomatic

  • Red cells:

    • may be present in UTI

    • chemical tests may be more sensitive than microscopy as a result of the detection of haemoglobin released by haemolysis

    • refer patients with persistent haematuria post-UTI to urology

  • White blood cells/ leucocytes:

    • white cells ≥107 WBC/L (≥104 WBC/mL) are considered to represent inflammation in urinary tract, this includes the urethra

    • white cells can be present in older people with asymptomatic bacteriuria, as the immune system does not differentiate colonisation from infection

  • Sterile pyuria

    • in sterile pyuria, consider Chlamydia trachomatis (especially if 16–24 years), other vaginal infections, other nonculturable organisms including tuberculosis or renal pathology

    • if recurrent pyuria with UTI symptoms, discuss with local microbiologist as lower counts down to 105 cfu/L (102 cfu/mL) may be significant. Higher volume of urine may need to be cultured, including for fastidious organisms

  • For all patients:

    • take into account of antibiotic susceptibility results and resistance when deciding on management and reviewing antibiotic treatment

  • Follow up:

    • do not send follow-up urine unless pregnant, or advised by the laboratory

    • consider non-urgent referral for bladder cancer in patients >60 years with recurrent/persistent unexplained UTIs

 
NICE.jpg
PHE.png

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