Clinical Notes : Dermatology

187. Dupuytren Contracture


What is Dupuytren contracture ?

Dupuytren contracture, also known as Dupuytren disease, is a progressive fibrosing disorder of the fingers and palm of the hand.


It results in the development of nodules and thickened cords in the palmar fascia which may lead to contractures of the fingers (1).


In later stages, structural changes also involve flexion contractures of the joints.


Who gets Dupuytren contractutere ?

Dupuytren contracture is a relatively common disorder that occurs with advancing age.


About 5–15% of Caucasian males over the age of 50 are affected (2).

There is a higher incidence in younger men than in women, but there are no significant differences in either sex by the ninth decade of life.

It is rare in Asians and African Americans.


What causes Dupuytren contracture ?


The exact cause of Dupuytren contracture is unknown.


It is associated with the following factors (3):

  • Genetic predisposition

  • Alcoholism

  • Smoking

  • Manual labour

  • Diabetes

  • Epilepsy

  • Palmar fasciitis

  • Other localised fibroses

  • Hand trauma.


Dupuytren contracture may be inherited as a familial condition or it may occur sporadically.


The reason for the dose-dependent association of alcoholism and cigarette smoking with Dupuytren contracture is not understood.

The incidence of Dupuytren contracture is two to five times higher in manual labourers than in office workers, possibly due to repetitive movements and vibration (4).


The association with epilepsy has been reported inconsistently and may be due to anti-epileptic medications.

What are the clinical features of Dupuytren contracture ?


A Dupuytren contracture is localised to one or both palms and fingers.

The disease classically presents in the half of the palm involving the fourth and fifth digits, and it may also affect the third finger.


The first sign is a palmar nodule, which may then progress to a cord (5).


Contractures occur later in the progression of Dupuytren contracture resulting in difficulty straightening the affected fingers.


Additional features may include:

  • Pits or puckering of the skin over the palm

  • Reduced movement of the finger(s)

  • Inflammation (redness, swelling, hotness, pain).

What are the complications of Dupuytren's contracture ?

Without treatment, Dupuytren contracture can lead to immobility of the fingers, resulting in loss of function of the affected hand.

There are no systemic complications associated with Dupuytren contracture.

How is Dupuytren's contracture diagnosed ?

Dupuytren contracture is diagnosed clinically and no investigations are required.

What is the differential diagnosis of Dupuytren's contracture ?

Dupuytren contracture should be distinguished from the following conditions.

  • Palmar fibromatosis (fasciitis) — this is characterised by flexion contractures affecting all the fingers. Palmar fibromatosis is associated with malignancy.

  • Diabetic cheiroarthropathy — this results in limited joint mobility of all fingers, sparing the thumb. Nodules and cords are absent.

  • Camptodactyly — this is a genetic disorder causing flexion deformities of the proximal interphalangeal joint.

  • Scars or disability from previous trauma to the hand.

  • Volkmann ischaemic contracture — this is a claw-like deformity of the hand, fingers and wrist which affects children after supracondylar fractures of the humerus.

  • An inflammatory joint disease such as rheumatoid arthritis.

What is the treatment of Dupuytren's contracture ?

Non-operative treatment

Non-operative treatment for mild Dupuytren contracture may include splinting (external fixation), which may reduce discomfort and lengthen the neurovascular bundle. It is uncertain if splinting, massage or hand exercises stop the progression of contractures (6).

Intralesional steroid injections with lignocaine may reduce tenderness and disease progression, but are not effective once cords and contractures have developed.

Experimentally, 90% of patients treated with Clostridium histolyticum collagenase injections are reported to have achieved full extension of the proximal interphalangeal (PIP) joint after a single treatment (7).

The contractures tend to recur more frequently at the PIP joint than at the metacarpophalangeal (MCP) joint.


Operative treatment

Surgery is the main treatment for extensive contractures and impaired hand function.


Indications for surgery are typically contractures > 30–40° at the MCP joint and > 20° at the PIP joint.

The aim is to restore function to the hands and reverse contractures in the fingers.


The surgical procedures for Dupuytren contracture include:

  • Fasciectomy (resection of the diseased cords/bands)

  • Fasciotomy (transection without removal of the diseased cords/bands).

These procedures can be done openly or using a percutaneous (needle) approach, with or without excision of overlying skin.


Surgery is more effective for contractures involving MCP joints than for those involving the PIP joints.

The recurrence rate after surgery is high, especially in younger patients.


Limited fasciectomy is indicated for patients with loss of function of the affected hand due to progressive contracture.

An isolated lesion with a single cord or band responds better to surgery than diffuse forms of the disease and can be operated on more aggressively.

Percutaneous needle fasciotomy is less invasive than fasciectomy with fast recovery and low complication rates, but the recurrence rate is up to 65% within 3 to 4 years (8).


The risks associated with a surgical procedure for Dupuytren contracture include:

  • Damage to the nerves and flexor tendons

  • The formation of pseudoaneurysms.


A surgical procedure can result in complex regional pain syndrome with stiffening of the affected fingers, a complication that is more likely to arise after general anaesthesia than when an intravenous regional block or axillary block is used (9).


Dupuytren contracture

DermNetNZ  (CCPL)


1. Smith PJ.

Lister's the hand: diagnosis and indications.

4th ed. England: 2002; 523–38.

2. Hindocha S, McGrouther DA, Bayat A.

Epidemiological evaluation of dupuytren’s disease incidence and prevalence rates in relation to etiology.

Hand 2009; 4(3): 256–69. DOI: 10.1007/s11552-008-9160-9. 



3. Townley WA, Baker R, Sheppard N, Grobbelaar AO.

Dupuytren's contracture unfolded.

BMJ 2006; 332: 397–400. DOI: 332/7538/397. 


4. Liss GM, Stock SR.

Can dupuytren's contracture be work‐related?: Review of the evidence.

Am J Ind Med 1996; 29: 521–32. 


5. Gudmundsson KG, Jonsson T, Arngrimsson R.

Guillaume dupuytren and finger contractures.

Lancet 2003; 362(9378): 165–8. doi: S0140-6736(03)13871-8.


6. Larocerie-Salgado J, Davidson J.

Nonoperative treatment of PIPJ flexion contractures associated with Dupuytren’s disease.

J Hand Surg Eur Vol 2012; 37: 722–7.


7. Watt AJ, Curtin CM, Hentz VR.

Collagenase injection as nonsurgical treatment of dupuytren's disease: 8-year follow-up.

J Hand Surg 2010; 35: 539. 


8. Van Rijssen AL, Ter Linden H, Werker PM.

Five-year results of a randomized clinical trial on treatment in Dupuytren's disease: percutaneous needle fasciotomy versus limited fasciectomy.

Plast Reconstr Surg 2012; 129: 469–77. 


9. Reuben SS, Pristas R, Dixon D, Faruqi S, Madabhushi L, Wenner S.

The incidence of complex regional pain syndrome after fasciectomy for Dupuytren's contracture: A prospective observational study of four anesthetic techniques.

Anesth Analg 2006; 102: 499–503.


10. Gudmundsson KG, Arngrimsson R, Jonsson T.

Eighteen years follow-up study of the clinical manifestations and progression of Dupuytren's disease.

Scand J Rheumatol 2001; 30: 31–4. 


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